By P. Vijay Sarthy (auth.), S. Robert Hilfer, Joel B. Sheffield (eds.)
The eye has involved scientists from the earliest days of organic in vestigation. the variety of its components and the precision in their interplay make it a favourite version method for numerous developmental stories. the attention is a very invaluable experimental approach not just simply because its tissues supply examples of basic approaches, but in addition since it is a renowned and simply available constitution at very early embryonic a long time. as a way to offer an open discussion board for investigators engaged on all elements of ocular improvement, a sequence of symposia on ocular and visible devel opment was once initiated in 1973. a big aim of the symposia has been to foster verbal exchange among the elemental examine employee and the scientific neighborhood. it truly is our feeling that a lot may be realized on either side from this interplay. the assumption for a casual assembly permitting greatest ex switch of rules originated with Dr. Leon Candeub, who provided the nec essary driver that made the sequence a fact. every one symposium has targeting a unique point of ocular improvement. audio system were chosen to procedure similar subject matters from diverse perspectives.
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Herndon. 1987. Astrocytes playa role in regulation of synaptic density. Brain Res. 402:139-145. Nork, T. , I. H. L. Wallow, S. J. Sramek, and G. L. Anderson. 1987. MUller cell involvement in proliferative diabetic retinopathy. Invest. Ophthalmol. Vis. , Suppl. 28:123. , D. Turner and C. Cepko. 1987. Lineage analysis in the vertebrate nervous system by retrovirus-mediated gene transfer. Proc. Natl. Acad. Sci. USA 84:156-160. Ramon y Cajal, S. 1892. The Structure of the Retina. translated by S. A.
Semischematic diagram illustrating the results of the serial reconstructions. The drawings are arranged from left to right in a proposed sequence leading to the ontogenesis of rods in the goldfish retina (see text for details). Abbreviations: mitotic figure (*), immature rod (R), other abbreviations as in figures 4 and 5. Reprinted with permission from Develop. BioI. 122: 120 (1987) . nuclear layer with rod precursors. The clear association of these cells with MUller glia raises the obvious question whether some of these cells might be dividing MUller cells.
In the absence of specific neuronal-glial contact communication, like phenotype. the MUller cell derivatives "default" to the lensIn the same vein then MUller cell differentiation is intimately tied to and perhaps directed by the differentiating neurons with which they are in contact. These comments clearly contain speculation. The data do strongly support the notion that the differentiative state of MUller cells is very plastic. The functional dichotomy of neurons and glia 44 seen in the mature retina is typical of all complex neural tissue.
Cell Interactions in Visual Development by P. Vijay Sarthy (auth.), S. Robert Hilfer, Joel B. Sheffield (eds.)